Total Asthma Control Yields Best Quality of Life

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advairNEW YORK (Reuters Health) Jan 04 - Total control of asthma, in accordance with guidelines from the Global Initiative for Asthma at the National Institutes of Health, results in the best quality of life, a new report indicates.

The results show that a tangible improvement in quality of life is seen when asthma is totally controlled rather than simply well controlled.

As reported in the European Respiratory Journal for January, Dr. E. D. Bateman, from the University of Capetown in South Africa, and colleagues administered the Asthma Quality of Life Questionnaire (AQLQ) to 1994 patients participating in a study comparing the efficacy of fluticasone alone or in combination with salmeterol.

The subjects were divided into three groups based on the degree of asthma control achieved during the 52-week study: totally controlled, well controlled, or not well-controlled.

The efficacy analysis showed that salmeterol/fluticasone improved the odds of total asthma control compared with fluticasone alone.

All three groups experienced improvements in quality of life during the study period. However, by the end of the study, patients with totally controlled asthma had significantly higher AQLQ scores than did those with well-controlled disease, who, in turn, had higher scores than those without well-controlled asthma (p < 0.001 for both).

"These results confirm that near-normal health-related quality of life can be achieved when treatment aims for total control of asthma, and that results with salmeterol/fluticasone propionate combination are superior to fluticasone propionate alone," the researchers conclude.

source - Reuters